To this dismissal of non-isolation I would like to counter-propose an unpopular but extremely non-paradigm theoretical alternative. It may be that we (all material and energy including biological organic organisms) are already “universe-hopping” routinely and have no way of self-referentially knowing this common occurrence. A common poetic reference would be the person who exclaims “at that moment my whole world changed”. Genetic mutations and odd behaviors wouldn’t be randomness of mistakes or adaptations, they would be changes popping in and out of enmeshed universes so similar the jump goes unobserved by the energy or makeup of hopper or surroundings on either universe. Universes so similar, so nearly mirrored, that hopping would be undetectable to even a theoretical physicist. I expect this notion to be resoundingly dismissed and scoffed. Just because Michel Eyquem de Montaigne was a muse does not preclude his speculations from occasionally turning out to have a glint of perspective.